In 1970, Dock Ellis pitched a no-hitter for the Pittsburgh Pirates against the San Diego Padres. In 1984, he claimed that he was high on LSD during the game and hardly recalls it:
I can only remember bits and pieces of the game. I was psyched. I had a feeling of euphoria. I was zeroed in on the (catcher's) glove, but I didn't hit the glove too much. I remember hitting a couple of batters and the bases were loaded two or three times. The ball was small sometimes, the ball was large sometimes, sometimes I saw the catcher, sometimes I didn't. Sometimes I tried to stare the hitter down and throw while I was looking at him. I chewed my gum until it turned to powder. They say I had about three to four fielding chances. I remember diving out of the way of a ball I thought was a line drive. I jumped, but the ball wasn't hit hard and never reached me.
Barbara Manning and the SF Seals (awesome name, no?) wrote a song about the game, which, along with a cool drawing and some more information about Dock Ellis, can be found here.
(via a convoluted path too complicated to attribute, but here are the Wikipedia pages for Dock Ellis and Barbara Manning. Trippy picture via The Psychedelic Shakespeare Solution.)